GUI Development in Python

Qt is the most capable desktop toolkit available to Python. PySide6 is the official Qt for Python binding under the LGPL, and PyQt6 is an alternative binding from Riverbank Computing under the GPL or a commercial license; the APIs are close, so the license usually decides. tkinter ships with Python and is fine for small tools, and CustomTkinter gives it a more modern look. wxPython wraps wxWidgets and uses native widgets on each platform, PyGObject is the binding for GTK, and Toga, from the BeeWare project, also targets native widgets per platform.

Kivy draws its own widgets and supports touch input and mobile platforms, and Dear PyGui is a GPU-accelerated toolkit suited to tools and dashboards. Another route is to build the interface with web technology: NiceGUI serves a UI to the browser from Python, pywebview shows HTML in a native window, and Flet builds apps rendered with Flutter. To ship a desktop app, see Distribution for PyInstaller and Nuitka.